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环氧乙烷(ETO)具有高度活性和渗透力的烷化剂。在一些试验系统中,它是一种已知致突变物,具有能与DNA起反应的一个活性基。它被作为医疗设备和用品的灭菌剂,以及食品、衣着和床上用品和制药设备的熏蒸剂。已使用20多年。据报道在用ETO医疗设备进行灭菌时,对灭菌的工作人员健康可能有影响,并显示染色体畸变增多。作者对加州、田纳西州及波多黎各三地使用ETO的9个工厂,其中接触100％ETO的50人及12％ETO的79人,估价了接触的可能影响,以未接触ETO的工人为对照。结果:(1)医学检查:81名ETO接触者
Ethylene oxide (ETO) A highly active and penetrating alkylating agent. In some experimental systems, it is a known mutagen that has a reactive group that reacts with DNA. It is used as a sterilizing agent for medical equipment and supplies, as well as fumigants for food, clothing and bedding and pharmaceutical equipment. Has been used for more than 20 years. It has been reported that sterilization with ETO medical equipment may have an impact on the health of sterilized staff and show an increase in chromosomal aberrations. The authors evaluated nine potential uses of ETO in California, Tennessee and Puerto Rico, with 50 of those approaching 100% of ETO and 79 of 12% of ETO assessing the likely impact of exposure against workers not exposed to ETO. Results: (1) Medical examination: 81 ETO contacts