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使用德国REICHERT-JUNG电动大切片机,对近年收治的14例小儿肾肿瘤标本,制备石蜡大切片,并进行形态学方面的研究,结果显示:①小儿肾肿瘤以Wilms为主;②Wilms瘤多由主瘤和卫星结节组成,提示多中心起源的可能;③在Wilms瘤中,间变细胞的存在可能是肿瘤逃避治疗、早期浸润及转移的异质性细胞,同时也提示Wilms瘤可能是具有异质性倾向的肿瘤;④缺血、坏死、血管瘤栓多在肿瘤中央区,提示无氧酵解并非肿瘤细胞唯一的供能方式,如对某些病例行肾动脉栓塞术,应比术前放、化疗有更确切的疗效;⑤具有淋巴类组织细胞增生者预后较好,提示术前后免疫抑制剂的应用,可能进一步提高疗效。
The use of German REICHERT-JUNG electric slicing machine, 14 cases of pediatric kidney tumors treated in recent years, prepared paraffin large sections, and morphological studies showed that: ① pediatric renal tumors dominated Wilms; ② Wilms tumor mostly by The main tumor and satellite nodules, suggesting the possibility of multicentric origin; ③ In Wilms tumor, the presence of anaplastic cells may be tumor escape therapy, early invasion and metastasis of heterogeneous cells, but also suggests that Wilms tumor may have Heterogeneous tendency of the tumor; â’¡ ischemia, necrosis, tumor thrombi in the central area of the tumor, suggesting that anaerobic glycolysis is not the only way for the tumor cells, such as in some cases of renal artery embolization, should be more than surgery Pre-release, chemotherapy has a more precise effect; ⑤ with lymphoid tissue cell hyperplasia prognosis is good, suggesting that preoperative and postoperative immunosuppressive agents may further improve the efficacy.