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目的:研究奥沙利铂联合5-氟尿嘧啶对食管癌患者的治疗效果及对血清胰岛素样生长因子1(IGF-1)及转化生长因子β(TGF-β_1)的影响。方法:选取2014年9月至2015年8月本院收治的78例食管癌患者,根据随机数字法分为观察组和对照组,39例每组。观察组采取奥沙利铂联合5-氟尿嘧啶进行治疗,对照组采取顺铂联合5-氟尿嘧啶进行治疗。比较两组患者治疗前后IGF-1、TGF-β_1水平变化,分析两组患者临床疗效和不良反应。结果:治疗后,观察组总缓解率显著高于对照组(P<0.05);两组患者IGF-1、TGF-β_1水平较治疗前显著降低(P<0.05),观察组IGF-1、TGF-β_1水平低于对照组(P<0.05);两组患者白细胞降低、血小板减少、贫血、脱发、神经感觉障碍、神经运动障碍不良反应率比较,差异无统计学意义(P>0.05);观察组患者恶心呕吐、口腔炎、腹泻等不良反应发生率均低于对照组(P<0.05)。结论:奥沙利铂联合5-氟尿嘧啶方治疗食管癌的临床疗效显著,能够有效降低患者血清TGF-β_1及IGF-1水平,且不良反应少,安全性高。
Objective: To investigate the effects of oxaliplatin combined with 5-fluorouracil on the treatment of patients with esophageal cancer and its effect on serum insulin-like growth factor 1 (IGF-1) and transforming growth factor β (TGF-β 1). Methods: Seventy-eight patients with esophageal cancer who were treated in our hospital from September 2014 to August 2015 were divided into observation group and control group according to random number method and 39 cases in each group. The observation group was treated with oxaliplatin combined with 5-fluorouracil, while the control group was treated with cisplatin plus 5-fluorouracil. The changes of IGF-1, TGF-β 1 levels before and after treatment were compared between the two groups, and the clinical efficacy and adverse reactions of the two groups were analyzed. Results: After treatment, the total remission rate in the observation group was significantly higher than that in the control group (P <0.05). The levels of IGF-1 and TGF-β 1 in both groups were significantly lower than those before treatment (P <0.05) (P <0.05). There was no significant difference between the two groups in leukopenia, thrombocytopenia, anemia, alopecia, neurosensory disorders and neurological dyskinesia (P> 0.05) The incidence of nausea and vomiting, stomatitis and diarrhea were lower in the patients than in the control group (P <0.05). Conclusion: Oxaliplatin combined with 5-fluorouracil treatment of esophageal cancer clinical significant effect, can effectively reduce the serum TGF-β 1 and IGF-1 levels, and adverse reactions, high safety.