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造血干血胞的调挂、增殖、分化过程中需要一系列的造血细胞生长因子的参与,近年来某些造血因子的氨基酸密码顺序已经清楚,能通过基因工程合成,并初步应用于临床研究。 1、红细胞生成素(EPO)。糖蛋,白分子量39,000～70.000,作用于G1期的造血祖细胞,促进其分化为原始红细胞,对已经分化的红细胞也有作用。体外培养证明,正常人骨髓、外周血细胞无外源性EPO,红系爆式集落(BFU—E)、红系
The hematopoietic stem cells require transfer of hematopoietic growth factors during the process of transfer, proliferation and differentiation. In recent years, the amino acid sequence of some hematopoietic factors has become clear and can be synthesized by genetic engineering and initially used in clinical research. 1, erythropoietin (EPO). Glycogen, the white molecular weight of 39,000 ~ 70.000, acting on the G1 phase of hematopoietic progenitor cells, and promote their differentiation into primitive red blood cells, have been differentiated erythrocytes also have effect. Proved in vitro, normal human bone marrow, peripheral blood cells without exogenous EPO, red blast colonies (BFU-E), red line