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目的:探讨胃肠间质瘤(gastrointestinal stromal tumor,GIST)的临床特点、组织病理学和免疫组织化学特点及其治疗方法。方法:对本院胃肠外科2002年1月-2008年6月收治的39例G1ST患者的临床表现、手术处理、病理检查及免疫组织化学的特点进行回顾性分析。结果:39例均进行了手术治疗,GIST主要发生在胃20例(20/39,51.28%)和小肠12例(12/39,30.77%),其他部位少见。CD117阳性表达率为92.31%,CD34阳性表达率为82.05%。结论:GIST缺乏特征性临床表现,术前确诊率低,其确诊依赖病理检查,CD117和CD34对GIST具高度敏感性。GIST的治疗方法以手术切除为主。
Objective: To investigate the clinical features, histopathology, immunohistochemistry and treatment of gastrointestinal stromal tumor (GIST). Methods: The clinical manifestations, surgical treatment, pathological examination and immunohistochemical features of 39 patients with G1ST admitted to our hospital from January 2002 to June 2008 were retrospectively analyzed. Results: All the 39 patients underwent surgical treatment. GIST mainly occurred in 20 (39/51, and 58%) of the stomach and in 12 (12/39, 30.77%) of the small intestine. The other sites were rare. The positive rate of CD117 was 92.31% and the positive rate of CD34 was 82.05%. Conclusions: GIST lacks characteristic clinical manifestations and preoperative diagnosis rate is low. Its diagnosis depends on pathological examination. CD117 and CD34 are highly sensitive to GIST. GIST treatment mainly surgical resection.