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虽然70%左右的晚期卵巢癌患者经标准治疗(肿瘤细胞减灭术加以铂类为基础的联合化疗)后可达临床完全缓解(CCR),但是70%的CCR患者仍将复发。其根本原因在于使患者达到CCR的诱导化疗(一线化疗)未能将肿瘤细胞减灭术后残存的肿瘤细胞完全杀灭。化疗杀伤肿瘤细胞遵循一级动力学规律,
Although about 70% of advanced ovarian cancer patients achieve clinically complete response (CCR) after standard therapy (cytocidal cytotoxic surgery combined with platinum-based chemotherapy), 70% of CCR patients will still relapse. The fundamental reason is that patients with CCR induced chemotherapy (first-line chemotherapy) failed to completely eliminate the remaining tumor cells kill tumor cells. Chemotherapy to kill tumor cells to follow the first-order kinetics,