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目的探讨淋巴瘤相关噬血细胞综合征(LAHS)的~(18)氟-氟代脱氧葡萄糖(~(18)F-FDG)PET/CT显像特征及预后的影响因素。方法回顾性分析29例LAHS患者~(18)F-FDG PET/CT显像资料及临床资料,计算脾脏、骨髓、淋巴结标准摄取值(SUV_(SP)、SUV_(BM)、SUV_(LD)),分析影响LAHS预后的相关因素。结果 24例脾肿大患者SUV_(SP)为4.21(2.15,12.50);22例骨髓~(18)F-FDG摄取增高患者SUV_(BM)为2.62(1.38,10.00);12例淋巴结肿大患者SUV_(LD)为6.24(3.46,10.31)。SUV_(SP)、SUV_(BM)、高三酰甘油、低纤维蛋白原、病理类型及EB病毒感染是影响LAHS预后的相关因素(P<0.05),而SUV_(BM)和EB病毒感染是影响LAHS的独立预后因素(P<0.05)。结论 LAHS的~(18)F-FDG PET/CT显像多表现为脾脏、骨髓的SUV增高,SUV_(BM)及EB病毒感染是影响LAHS预后的独立危险因素。
Objective To investigate the characteristics and prognostic factors of 18F-18F-FDG PET-CT in lymphoma-associated hemophagocytic syndrome (LAHS). Methods The data of 18 F-FDG PET / CT imaging and clinical data of 29 patients with LAHS were retrospectively analyzed. The standard values of spleen, bone marrow and lymph node (SUV SP, SUV BM, SUV LD) , Analyze the relevant factors affecting the prognosis of LAHS. Results The SUV (SP) of 24 splenomegaly patients was 4.21 (2.15,12.50). The SUV BMD of 2.22 (1.38,10.00) patients with increased bone marrow 18F-FDG uptake was 2.62 (1.38,10.00). Among the 12 patients with enlarged lymph nodes SUV_ (LD) was 6.24 (3.46, 10.31). SUV_ (SP), SUV_ (BM), high triglyceride, low fibrinogen, pathological type and Epstein-Barr virus infection were the related factors influencing the prognosis of LAHS (P <0.05), while SUV_ (BM) Independent prognostic factors (P <0.05). Conclusion The ~ (18) F-FDG PET / CT scans of LAHS are spleen and increase the SUV of bone marrow. SUV BM and EBV infection are independent risk factors for the prognosis of LAHS.