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目的分析不良妊娠与大Y染色体核型之间的关系。方法外周血淋巴细胞G显带核型分析,统计生育异常男性染色体异常核型者,设立同期体查核型为46,XY的正常男性为对照组。结果5152例受检者共检出异常核型876例,其中大Y染色体246例,检出率为4.75%(246/5152)、占异常核型的28.08%(246/876)。临床主要表现为男性不育、女性习惯性流产、死胎、畸形儿等。结论大Y染色体核型具有一定的遗传效应,对精子的生成和配偶的不同类型的不良妊娠有一定的临床关系。
Objective To analyze the relationship between adverse pregnancy and large Y chromosome karyotype. Methods Peripheral blood lymphocytes G-banding karyotype analysis, statistical abnormalities in male genital abnormalities karyotype, the establishment of the same period check nucleated type 46, XY normal male control group. Results There were 876 abnormal karyotypes in 5152 subjects, of which 246 were large Y chromosomes. The detection rate was 4.75% (246/5152), accounting for 28.08% (246/876) of abnormal karyotypes. Main clinical manifestations of male infertility, female habitual abortion, stillbirth, deformed children and so on. Conclusion Large Y chromosome karyotype has certain genetic effect, and has certain clinical relationship to sperm production and spousal different types of adverse pregnancy.