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结合文献复习并提出胰高糖素瘤综合征诊断标准及治疗方案。报告2例胰高血糖素瘤，1例伴肝转移行胰体尾切除、肝活检，1例伴肝及肋骨转移行胰体尾部分切除，脾、胆囊切除、肝活检。胰高血糖素瘤属胰腺内分泌肿瘤中较为罕见的疾病，本病的主要临床特征为迁移性反复皮疹及舌炎、糖尿病、消瘦、贫血等。治疗原则上以手术切除为主，良性者可获长期治愈，恶性者应辅以化疗。
Review the literature and propose diagnostic criteria and treatment options for glucagonoma syndrome. Report 2 cases of glucagonoma, 1 case with liver metastasis pancreatic body end resection, liver biopsy, 1 case with liver and ribs metastasis of pancreatic body part of the tail, spleen, cholecystectomy, liver biopsy. Glucagonoma is a relatively rare disease in pancreatic endocrine tumors. The main clinical features of this disease are migratory recurrent rash, glossitis, diabetes, weight loss, and anemia. In principle, surgical resection is the main treatment. Benign patients can be cured for a long time. Malignant patients should be supplemented with chemotherapy.