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目的:了解阿司咪唑上市后心脏毒性的类型及发生原因。方法:收集1991～2007年国内公开发表有关阿司咪唑心脏毒性的报道文献30篇,共38例。通过文献计量分析法,对不良反应文献所涉及患者资料、用药方法等进行回顾性分析。结果:阿司咪唑的心脏毒性表现为尖端扭转型室性心动过速、室性心动过速、房室传导阻滞和QT间期延长。其发生原因多与过量有关。结论:阿司咪唑心脏毒性作用绝大多数为A类不良反应,可预知,可预防,通过选择适应证,控制用药剂量可予以预防。
Objective: To understand the type of cardiac toxicity after asimizumab is listed and its causes. Methods: From 1991 to 2007, 30 published articles about astemizole cardiotoxicity were collected in our country, totally 38 cases. By means of bibliometric analysis, the data of patients involved in adverse reactions, medication methods were retrospectively analyzed. Results: The cardiac toxicity of astemizole showed torsades de pointes, ventricular tachycardia, atrioventricular block and QT prolongation. The reasons for its occurrence and overdose. Conclusion: Astelimidine cardiotoxicity most of the A class adverse reactions, predictable, preventable, by selecting indications, dosage can be controlled by prevention.