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1977年Raghavan 等报告,长期接触铅的工人红细胞中有一种与铅结合的低分子蛋白质,而不与铅接触者则无此种蛋白。因此,作者推想:此种蛋白是由铅诱导合成的。这些发现经Lolin 等证实,并表明,长期接触铅的工人红细胞中此种蛋白量(用凝胶过滤和紫外吸收测得)与全血铅含量显著相关。由于这种蛋白与金属巯基组氨酸三甲基内盐(mctallothionein,MT)的相似性,促使作者引用已建立的测定组织中MT 的方法(镉饱和法)于红细胞中铅结合蛋白的测定。试验对象,试验组为21名成年男性再生铅冶炼者,其全血铅浓度长期增高(0.7～2.8μmol/L),对照组为14名不接触铅的健康成人,全血铅浓度<0.8μmol/L。
Raghavan et al. Reported in 1977 that there was a lead-bound low-molecular-weight protein in the red blood cells of workers exposed to lead for a long time, but no such contact with lead. Therefore, the authors hypothesize: This protein is induced by lead synthesis. These findings were confirmed by Lolin et al. And showed that this amount of protein (measured by gel filtration and UV absorbance) in the erythrocytes exposed to long-term lead exposure was significantly associated with whole blood lead levels. Because of the similarities between this protein and the metal mctallothionein (MT), the authors prompted the authors to cite the established method for the determination of lead-binding proteins in erythrocytes by the established method for determination of MT in tissues (cadmium saturation method). In the test group, 21 adult male lead lead smelters had a long-term elevated lead concentration (0.7-2.8 μmol / L) in whole blood and 14 healthy adults without lead exposure in the control group. The lead concentration in whole blood was less than 0.8 μmol / L.