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目的：探讨一侧心室压力负荷时，对对侧心室功能及结构的影响。方法：健康杂种犬７只，环缩肺动脉和主动脉，造成急性右心室和左心室压力负荷的动物模型，并应用心导管术观察血液动力学、应用超声心动图观察心室形态改变。结果：环缩肺动脉后，右心室压力明显升高，左心室压力降低，跨隔压力阶差缩小，舒张末期左心室偏心指数增大（由对照值由１０２±０１３增至１８８±０５８，Ｐ＜００１）。环缩主动脉后，右心室压力随左心室压力的升高而增高。环缩肺动脉和主动脉后右心室射血分数较环缩前均明显降低（Ｐ均＜００１）。跨隔压力阶差与偏心指数呈显著负相关（ｒ＝－００８９，Ｐ＝０．０１６）。结论：一侧心室压力负荷可影响对侧心室功能
Objective: To investigate the effect of ventricular pressure load on contralateral ventricular function and structure. Methods: Seven healthy mongrel dogs were randomly divided into pulmonary artery and aorta. The animals were subjected to acute right ventricular (LV) and left ventricular (LV) pressure load. Cardiac catheterization was used to observe hemodynamics. Echocardiography was used to observe changes of ventricular morphology. Results: After the pulmonary artery was contracted, the pressure of the right ventricle was significantly increased, the pressure of the left ventricle was decreased, the transmural pressure gradient was reduced and the end-diastolic left ventricular eccentricity index increased from 102 ± 013 to 1 88 ± 058, P <001). Systolic aorta, right ventricular pressure increased with left ventricular pressure increased. Systolic pulmonary arteries and aorta right ventricular ejection fraction were significantly reduced compared with before constriction (P all <0.01). There was a significant negative correlation between translamination pressure gradient and eccentricity index (r = -0.089, P = 0.016). Conclusion: A ventricular pressure load may affect contralateral ventricular function