华法林与苯溴马隆联用致国际标准化比值升高

• 作 者: 刘佳 许建国 邹颖
• 机 构: 江苏省苏北人民医院药剂科,江苏省人民医院药剂科,
• 出 处: 药物不良反应杂志
• 发表日期: 2013年01期
• 关键词: Warfarin Benzbromarone International normalized ratio Drug interaction

1例45岁男性患者,因扩张型心肌病、心房颤动、肺动脉高压、心力衰竭给予托拉塞米、呋塞米、螺内酯、培哚普利、美托洛尔、头孢地嗪、多烯磷脂酰胆碱治疗,同时口服华法林2.5 mg,1次/d。第3天实验室检查:国际标准化比值(INR)1.16,尿素8.9 mmol/L,尿酸625μmol/L。加服苯溴马隆50 mg,3次/d。次日患者INR升至3.43,第9天升至4.56。当日停用华法林。停用华法林第7天INR降至1.28,第14天恢复华法林2.5 mg口服,1次/d。6 d后,INR升至3.52。当日停用苯溴马隆,次日停用华法林。3 d后,INR降至1.98。

One 45-year-old male patient was given torsemide, furosemide, spironolactone, perindopril, metoprolol, cefodizime, polyenephospholipids for dilated cardiomyopathy, atrial fibrillation, pulmonary hypertension, and heart failure Choline treatment, while oral warfarin 2.5 mg, 1 / d. The third day laboratory tests: the international standardization ratio (INR) 1.16, urea 8.9 mmol / L, uric acid 625μmol / L. Add benzbromarone 50 mg, 3 times / d. INR rose to 3.43 on the next day and rose to 4.56 on the ninth day. Warfarin was discontinued the same day. Warfarin withdrawal INR 7 days to 1.28, the first 14 days to return warfarin 2.5 mg orally, 1 / d. After 6 days, INR rose to 3.52. Benzbromarone will be suspended on the same day and warfarin will be discontinued the next day. After 3 days, INR dropped to 1.98.