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制备标准吸收图谱:精密秤取安乃近0.4克、0.6克、0.8克、1.0克、1.2克、用水溶解至50毫升容量瓶中,用水稀释至刻度,使每5毫升含安乃近40.0毫克,60.0毫克,80.0毫克和100.0毫克。精密量取各溶液5毫升于烧杯中,各加亚硝酸钠0.5克及2.0N盐酸溶液20毫升,缓缓加热并不断搅拌7分本文报导,安乃近(Dipyrone)及其制剂与亚硝酸盐生成黄色衍生物,在碱性介质下于403毫微米处有最大吸收峰,可进行比色测定。本法具有可测得安乃近的低浓度含量以及制剂中含有的抗氧剂亚硫酸钠不干扰测定之优点。其反应机理设想如下:
Preparation of standard absorption spectra: Accurate to take nearly 4 grams of Amphenol, 0.6 grams, 0.8 grams, 1.0 grams, 1.2 grams, dissolved in water to a 50 ml volumetric flask, diluted with water to the mark, so that every 5 ml containing 40.0 mg , 60.0 mg, 80.0 mg and 100.0 mg. The precise amount of each solution 5 ml in a beaker, each with 0.5 g of sodium nitrite and 2.0 N hydrochloric acid solution 20 ml, slowly heating and stirring constantly 7 minutes reported in this article, Dipyrone (Dipyrone) and its preparation with nitrite The resulting yellow derivative has a maximum absorption peak at 403 nm in an alkaline medium for colorimetric determination. This method has the advantages of measurable concentrations of dipyrone and the non-interfering assay of the antioxidant sodium sulfite contained in the formulation. The reaction mechanism is assumed as follows: