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目的探讨转移因子联合阿昔洛韦治疗手足口病的临床疗效。方法选取2013年5月—2014年3月乐安县人民医院收治的手足口病患儿72例,按治疗方法不同分为研究组38例与对照组34例。两组患儿均予以基础治疗,对照组患儿予以单纯的阿昔洛韦治疗,研究组患儿在对照组基础上予以转移因子治疗。观察两组患儿治疗前后免疫指标〔免疫球蛋白G(IgG)、CD_4~+T细胞(CD_4~+)、CD_8~+T细胞(CD_8~+)、CD_4~+/CD_8~+〕变化情况、临床疗效及不良反应发生情况。结果治疗前两组患儿IgG、CD_4~+、CD_8~+、CD_4~+/CD_8~+比较,差异无统计学意义(P>0.05);治疗后研究组患儿IgG、CD_4~+、CD_4~+/CD_8~+高于对照组,CD_8~+低于对照组,差异有统计学意义(P<0.05);研究组患儿总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿均未发生严重不良反应。结论转移因子联合阿昔洛韦治疗手足口病的临床疗效显著,可改善患儿免疫功能,且不良反应少。
Objective To investigate the clinical efficacy of transfer factor combined with acyclovir in the treatment of hand, foot and mouth disease. Methods Seventy-two children with hand-foot-mouth disease admitted from May 2013 to March 2014 in Le’an County People’s Hospital were divided into study group (38 cases) and control group (34 cases) according to different treatment methods. Two groups of children were given basic treatment, the control group of children treated with acyclovir alone, the study group children in the control group on the basis of transfer factor therapy. The changes of immune indexes (such as immunoglobulin G (IgG), CD 4 + T cells (CD 4+), CD 8 + T cells (CD 8+), CD 4+ / CD 8+] before and after treatment were observed in both groups , Clinical efficacy and adverse reactions occurred. Results There was no significant difference in IgG, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 ~ + between the two groups before treatment (P> 0.05) (P <0.05). The total effective rate in study group was higher than that in control group, the difference was statistically significant (P < 0.05). No serious adverse reactions occurred in both groups. Conclusion The combination of transfer factor and acyclovir in the treatment of hand, foot and mouth disease has significant clinical effect, which can improve children’s immune function with less adverse reactions.