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以弥拜霉素类似物依维菌素为原料,根据类同合成法和亚结构连接法原理,对依维菌素进行脱糖,再与相应的酰氯进行酯化、肟化反应制得两个系列弥拜霉素类似物化合物4Ia～5IId,所有目标化合物都通过核磁共振氢谱、高分辨质谱的确认,并分别对朱砂叶螨(Tetranychus cinnabarinus)、南方粘虫(Mythimna sepatara)和蚕豆蚜(Aphis fabae)进行室内杀虫活性测定,结果表明所有衍生物均表现出不同程度的杀虫活性,其中化合物4IIa和4IIb对粘虫和蚜虫表现出很高的杀虫活性.
With mebendazole analogue Ivermectin as raw material, according to the principle of similar synthesis and substructure ligation, Ivermectin was decarboxylated, and then esterified with the corresponding acid chloride to form oxime A series of mepiquat analogues 4Ia ~ 5IId, all the target compounds were confirmed by 1H nuclear magnetic resonance spectroscopy, high resolution mass spectrometry, and Tetranychus cinnabarinus, Mythimna sepatara and Myzus persicae (Aphis fabae). The results showed that all the derivatives showed different degrees of insecticidal activities, of which compounds 4IIa and 4IIb showed high insecticidal activity against armyworms and aphids.