Pharmacokinetic Study of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats

• 作 者: Xiao-xiao Liu Yong-ping Jiang
• 机 构: BiopharmaceuticalR＆DCenter,BiopharmagenCorp.
• 出 处: 中国医学科学杂志：英文版
• 发表日期: 2010年1期
• 关键词: 重组人粒细胞集落刺激因子 生物药效率 药代动力学 重组细胞 recombinant human granulocyte colony-stimulating f
• 基金项目: Supported by State Scientific Key Projects for New Drug Research and Development （2009ZX09102-250）, High-tech Research Project for Medicine and Pharmacology of Jiangsu province （BG20070605）

Objective To study the pharmacokinetics of a novel recombinant human granulocyte colonystimulating factor (rhG-CSFa) in rats and to determine the proteolytic rates of rhG-CSFa in the whole blood and serum of rats in vitro. Methods The pharmacokinetics of