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在具有生物活性的有机化合物中,碳水化合物日见重要。目前,我们研究的第一个目标是用很简单的化合物——烯丙基碘——为原料,合成各种糖。第二个目标是将二个糖连起来成为甙,即多糖。这种立体选择性的连接,即甙键的α-型或β-型的连接,在合成化学中非常重要,但至今还没有解决。我们是怎么进入到不对称合成这一领域的呢?我们曾在1975—1978年进行了含氮鎓盐的研究,发现如用—光学活性的仲醇,和鎓盐反应后,再用不同的试剂处理,可以得到构型反转的光学活性的醇,卤代物,硫醇或胺。
Among biologically active organic compounds, carbohydrates are of paramount importance. At present, the first goal of our research is to synthesize various kinds of sugars using the very simple compound allyl iodide as raw material. The second goal is to link the two sugars into glycosides, polysaccharides. This stereoselective linkage, the linkage of the a-type or beta-type of the glycosidic bond, is of great importance in synthetic chemistry but has so far not been solved. How did we move into the field of asymmetric synthesis? We conducted a study of nitrogen-containing onium salts from 1975 to 1978 and found that after reaction with an onium salt with an optically active secondary alcohol, different Reagent treatment can provide optically active alcohols, halides, thiols, or amines that are inverted in configuration.