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目的：了解大剂量维生素Ｂ６在实验性动脉粥样硬化的保护作用与免疫因素的关联。方法：测定实验性高胆固醇家兔血清抗单核细胞抗体，以及白细胞移动抑制试验。结果：１）维生素Ｂ６有明显降低血胆固醇，减少动脉壁粥样斑块形成的作用；２）较长期喂胆固醇饲料，导致家兔细胞免疫反应下降，补充维生素Ｂ６可使细胞免疫反应维持原有水平；３）在无外来抗原诱导，较长期喂养高胆固醇饲料，可使家兔产生抗单核细胞抗体。结论：补充大剂量维生素Ｂ６可降低血胆固醇及减少动脉壁粥样斑块的形成，并能改善家兔细胞免疫状态，但未发现影响机体体液免疫。
Objective: To understand the protective effect of high-dose vitamin B6 in experimental atherosclerosis and immune factors. Methods: The serum anti-monocyte antibodies in experimental hypercholesterolemic rabbits and the leukocyte migration inhibition test were determined. Results: 1) Vitamin B6 significantly reduced blood cholesterol and reduced the formation of atherosclerotic plaque; 2) Cholesterol-based feed fed for a longer period led to a decrease in cellular immune response in rabbits. Supplementing with vitamin B6, the cellular immune response was maintained Level; 3) In the absence of foreign antigen-induced, longer-term feeding of high-cholesterol feed, rabbits can produce anti-monocyte antibodies. Conclusion: Supplementation of large doses of vitamin B6 can reduce blood cholesterol and reduce the formation of arterial plaque, and can improve cellular immune status in rabbits, but no body fluid immunity is found.