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鉴于神经体液过度激活是引起充血性心衰进行性加重的因素，作者通过漂浮导管血流动力学监测、彩色多普勒心功能观察、亚级量踏车运动试验、Holter心电监测和临床分析，研究了21例扩张型心肌病服用选择性β_1受体阻滞剂美托洛尔（Metoprolol）后的变化。发现患者平均肺毛细血管楔压和体循环阻力显著下降，心指数、左室搏功指数和左室舒张早期最大流速与房性充盈最大流速之比均显著升高；静息最大心率及其
In view of neurohumoral over-activation is caused by progressive worsening of congestive heart failure, the author through the floating catheter hemodynamic monitoring, color Doppler cardiac function tests, Asian treadmill exercise test, Holter ECG monitoring and clinical analysis , We investigated the changes of 21 patients with dilated cardiomyopathy treated with metoprolol, a selective beta-1 blocker. Found that the average pulmonary capillary wedge pressure and systemic resistance decreased significantly, cardiac index, left ventricular stroke index and left ventricular diastolic velocity of the maximum flow and the maximum filling rate of atrial filling were significantly increased; resting maximum heart rate and its