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目的 应用二甲基奶油黄（ＤＡＢ） 诱发大鼠肝癌，为了观察诱癌过程中大鼠ＩＬ－ ２ 、丙二醛（ ＭＤＡ） 动态变化及其相互关系。方法 在诱发大鼠肝癌的３ 个阶段分别取大鼠脾脏和外周血测定ＩＬ－ ２ 活性和丙二醛。结果 肝炎、肝硬化、肝癌期大鼠ＩＬ－ ２ 活性降低，ＭＤＡ 显著增高，Ｐ＜ ０ ．０５ 或０－０１ 。肝癌期大鼠ＩＬ－ ２ 活性与ＭＤＡ 呈负相关。结论 诱发大鼠肝癌过程中，ＩＬ－ ２ 活性逐步降低，ＭＤＡ 随着病情发展逐步增高，肝癌期ＩＬ－ ２ 活性下降与ＭＤＡ 的增高有关
Objective To use dimethyl cream yellow (DAB) to induce rat liver cancer in order to observe the dynamic changes of IL-2 and malondialdehyde (MDA) and their relationship in the process of carcinogenesis. Methods The levels of IL-2 activity and malondialdehyde were measured in the spleen and peripheral blood of rats induced by hepatic carcinoma. Results The activity of IL-2 in the rats with hepatitis, liver cirrhosis and hepatic cancer was decreased and MDA was significantly increased, P<0. 05 or 0-01. The activity of IL-2 in rats with hepatocellular carcinoma was negatively correlated with MDA. Conclusion During the process of hepatocarcinogenesis induced by rat, the activity of IL-2 gradually decreases, MDA gradually increases with the progression of the disease, and the decrease of IL-2 activity in the liver cancer period is related to the increase of MDA.