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目的：探讨经皮椎体成形术联合125I粒子植入治疗脊柱转移癌的围手术期护理。方法对40例脊柱转移癌的患者采取系统的护理管理，做好术前健康教育，心理营养支持，术中严密监测灌注剂在注射过程中的渗漏现象，密切观察生命体征，血氧饱和度及患者肢体活动，术后严密观察，积极预防并发症，并指导康复训练和防护宣教。结果所有患者在术后12h内疼痛明显缓解，术后无并发症发生。结论经皮椎体成形术联合125I粒子植入在治疗脊柱转移癌具有创伤小，安全有效，易于操作的特点，而规范、合理、有效的护理干预可提高疗效，预防并减少并发症的发生。“,”Objective To investigate the perioperative nursing of percutaneous vertebroplasty combine with 125I particle implantation treatment in spinal metastatic carcinoma . Methods 40 cases of patients with spinal metastatic carcinoma adopt to the system of nursing supervision and doing the preoperative health education, psythological nutritional support, In surgery closely monitored perfuse agent in the process of injecting the leakage phenomenon, close observation of vital signs, saturation of blood oxygen and the limbs activity in patients, in postoperative, close observation and actively prevent complications, to guide rehabilitation training and protection publicity and education. Results Postoperative within 12 hours all patients pain should be relieved in obviously, and no postoperative complications. Conclusion Percutaneous vertebroplasty combine with 125I particle implantation treatment in spinal metastatic carcinoma. This method have the characteristic of minimally wound, safe, effective and easy-to-manipulate, and standardized, reasonable and effective nursing intervention can enhance the effectiveness , prevent and reduce the incidence of complications.