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长期以来,许多教科书及文献杂志上均报导青霉素与维生素C不能在同一溶液中配伍,其原因是维生素C能使葡萄糖的pH值下降,从而引起青霉素在酸性介质中效价降低。但由于维生素C在临床上的广泛用途,许多医生习惯在输液中加入一定量的维生素C,鉴于配伍禁忌,只得将维生素C与青霉素分成二组液体输入。这样就给工作带来诸多不便。在大输液中加维生素C究竟会不会引起pH值降低,我们通过反复试验,得出结论:一定量的维生素C加在5％或10％的葡萄糖中以及其它的大输液中,不但不会使pH值下降,反而能使pH值升高。由于pH的升高,使得部分抗生素如青霉素、红
For a long time, many textbooks and literature magazines have reported that penicillin and vitamin C can not be in the same solution compatibility, the reason is that vitamin C can make glucose pH decreased, causing penicillin in acidic medium, the potency reduction. However, due to the wide-spread use of vitamin C in clinic, many doctors are accustomed to adding a certain amount of vitamin C in infusion. In view of incompatibility, vitamin C and penicillin have to be divided into two groups of liquid inputs. This will bring a lot of inconvenience to the work. In large infusion of vitamin C whether it will cause a decrease in pH, we have repeatedly tested, concluded: a certain amount of vitamin C plus 5% or 10% of glucose and other large infusion, not only will not The pH value, but can make the pH value. As the pH increases, making some antibiotics such as penicillin, red