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应用免疫组织化学技术，检测胆管癌３０例，胆囊癌２８例及胆道良性病变３０例组织Ｈ－ｒａｓＰ２１蛋白表达。结果表明，胆管癌３０例，Ｐ２１－ｒａｓ阳性１９例（６３．３％），胆管炎及囊肿１０例，Ｐ２１－ｒａｓ均为阴性，两者比较差异有显著性（Ｐ＜０．００５）。胆囊癌２８例，Ｐ２１－ｒａｓ阳性１６例（５７．１％），胆囊息肉和胆囊结石２０例，仅１例呈阳性，两者比较差异有显著性（Ｐ＜０．００５）。同时研究表明，Ｈ－ｒａｓＰ２１的阳性表达与性别、年龄无关，而与病理相一致。因此通过Ｈ－ｒａｓＰ２１的检测对诊断及鉴别诊断胆道良恶性肿瘤具有重要的价值。
H-rasP21 protein was detected by immunohistochemistry in 30 cases of cholangiocarcinoma, 28 cases of gallbladder carcinoma and 30 cases of benign biliary lesions. The results showed that there were 30 cases of cholangiocarcinoma, 19 cases of P21-ras positive (63.3%), 10 cases of cholangitis and cyst, P21-ras were negative, the difference was significant (P <0.005). Gallbladder cancer in 28 cases, P21-ras positive in 16 cases (57.1%), gallbladder polyps and gallbladder stones in 20 cases, only 1 case was positive, the difference between the two was significant (P <0.005). At the same time, studies have shown that the positive expression of H-rasP21 has nothing to do with gender, age, and consistent with the pathology. Therefore, the detection of H-rasP21 is of great value in the diagnosis and differential diagnosis of benign and malignant biliary tract tumors.