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钙是植物中常见的元素,因此由中草药制成的注射剂中均或多或少的含有钙。但如注射剂中含钙量较多时,则在皮下或肌肉注射时有强烈的刺激性,甚至会发生组织坏死。目前药典对注射液中Ca的含量尚无定量的控制测定,为此我们对中草药注射剂中钙的微量测定进行了研究。微量钙的测定常用的光度法是乙二醛双(乙—羟基缩苯胺)法(即GBHA法)。该法具有Mg~(2+)和碱金属离子不干扰测定的优点,但PO_4~(3-)有干扰,而磷是中草药中常见的元素,故必须消除PO_4~(3-)的干扰才能应用GBHA法。钙黄绿素是络合滴定测定钙的常
Calcium is a common element in plants, and therefore injections made from Chinese herbs contain calcium more or less. However, if the calcium content of the injection is large, it is strongly irritating when injected subcutaneously or intramuscularly, and even tissue necrosis may occur. At present, pharmacopoeia has no quantitative control over the content of Ca in injections. For this reason, we have conducted a study on the determination of calcium in Chinese herbal medicine injections. A common spectrophotometric method for the determination of trace calcium is the glyoxal bis(ethylhydroxyanilide) method (GBHA method). The method has the advantages of Mg 2+ and alkali metal ions not interfering with the measurement, but PO 4 - 3 - has interference, and P is a common element in Chinese herbs, so the interference of PO 4 - 3 must be eliminated Apply GBHA method. Calcein is often used for complexometric titration of calcium