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己糖的1,3—缩水内醚衍生物由于与在生理上有重要作用的血凝聚素TXA_2(ThromboxaneA_2)含有相同的2,6—dioxabicyclo[3.1.1]heptane的骨架,而受到化学界、生物化学界的重视。此外,它们的立体有规聚合,然后脱保护基,能得到(1→3)连接的多糖,后者是多糖的生物化学实验的宝贵的基准物。近年来,本研究组致力于1,3—缩水内醚糖衍生物的合成及构象研究,及由其制备寡糖、多糖的研究,先后合成了D—鼠李糖,L—鼠李糖,D—半乳
The 1,3-caprolactone derivative of hexose is chemically bound to the physiologically important hemagglutinin TXA_2 (Thromboxane A_2), which contains the same skeleton of 2,6-dioxabicyclo [3.1.1] heptane, Biochemistry community attention. In addition, their stereospecific polymerization followed by deprotection gives (1 → 3) linked polysaccharides, which are valuable fiducials for the biochemical experiments of polysaccharides. In recent years, our group has been devoted to the synthesis and conformational studies of 1,3-dimorpholinoether derivatives, as well as the research on their preparation of oligosaccharides and polysaccharides. D-rhamnose, L-rhamnose, D-half milk