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目的探讨肝动脉化疗栓塞术加用生物反应调节剂对老年人、中晚期原发生性肝癌的疗效。方法对不能手术的老年人中、晚期肝癌７６例，用顺铂、表阿霉素、ＩＬ－２、丝裂霉素、碘油、明胶海绵进行肝动脉化疗栓塞（ＨＡＥ）继而全身应用ＩＬ－２。ＨＡＥ与应用ＩＬ－２交替进行。结果１年生存率为５１．３％，其中以临床Ⅱ期患者，单发结节型及巨块型患者疗效较好。主要副作用为栓塞术后综合征，个别患者出现急性肝功能衰竭。结论肝动脉化疗栓塞加用生物反应调节剂可提高老年人中、晚期原发性肝癌的疗效及延长生存期。
Objective To investigate the efficacy of hepatic arterial chemoembolization plus biological response modifiers for the elderly and advanced primary liver cancer. Methods 76 cases of advanced and inoperable middle-aged liver cancer were treated with cisplatin, epirubicin, IL-2, mitomycin, lipiodol, and gelatin sponge for hepatic arterial chemoembolization (HAE) followed by systemic application of IL- 2. HAE alternates with applying IL-2. Results The 1-year survival rate was 51.3%. Among the patients with clinical stage II, single-nodular type and massive mass were better. The main side-effects were postoperative embolization syndromes and acute liver failure in individual patients. Conclusion Transcatheter arterial chemoembolization combined with biological response modifiers can improve the efficacy and prolong survival of elderly patients with advanced primary liver cancer.