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目的 探讨洛赛克、克拉霉素、阿莫西林三联根除儿童幽门螺杆菌 (Hp)感染的远近期疗效。 方法 经1 3C尿素呼吸试验 (1 3C UBT)及血清Hp IgG测定 2项阳性的反复腹痛儿 95例 ,随机分为治疗组 (60例 )与安慰剂组 (35例 ) ,治疗组接受洛赛克 0 .8mg/ (kg·d) ,每天一次 ,克拉霉素 1 5mg/ (kg·d) ,每天 2次 ,阿莫西林 30mg/ (kg·d) ,每天 3次 ,三联口服治疗 ;疗程 1周。停药后 1 ,3 ,6 ,1 2个月门诊随访 ,复查1 3C UBT及Hp IgG。 结果 1 .治疗组停药后 4周腹痛的总有效率 96 .7% ,而安慰剂组仅 34 .6 % ;治疗组Hp根除率为 90 % ,明显高于安慰剂组 1 4 .3 %。 2 .治疗组Hp根除后 3 ,6 ,1 2个月复查Hp再感染率分别为 1 .85 %、1 .85 %、3 .57%。 结论 1 .洛赛克等三联根除反复腹痛儿Hp感染临床效果显著 ,Hp根除率高 ,远近期疗效均好 ,1年再感染率低。2 .1 3C UBT监测Hp根除情况快捷准确。
Objective To investigate the short-term and long-term effects of Lectra, clarithromycin and amoxicillin in eradicating Helicobacter pylori (Hp) infection in children. Methods Two hundred and ninety-two patients with positive recurrent abdominal pain were measured by 1 3C UBT and serum Hp IgG and were randomly divided into treatment group (60 cases) and placebo group (35 cases). The treatment group received Losses (0 · 8 mg / (kg · d)) once a day, clarithromycin 15mg / (kg · d), twice a day, amoxicillin 30mg / (kg · d), 3 times a day, triple oral treatment; 1 week. The patients were followed up 1, 3, 6, 12 months after discontinuation, and 1 C UBT and Hp IgG were reviewed. The results showed that the total effective rate of abdominal pain in treatment group was 96.7% four weeks after drug withdrawal, while only 34.6% in placebo group. The eradication rate of Hp in treatment group was 90%, significantly higher than that in placebo group (14.3% . The re-infection rates of Hp in the treatment group after Hp eradication were 6.35%, 1.85% and 3.57% respectively at 3, 6 and 12 months after eradication. Conclusions 1. Lectra and other three triple eradication of recurrent abdominal pain in children with Hp infection clinically significant effect, Hp eradication rate, distant effect is good, 1 year re-infection rate is low. 2 .1 3C UBT Monitoring Hp Eradication is fast and accurate.