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良性前列腺肥大在老年人中很常见。它可阻塞尿道面引起很讨厌的排尿异常症状。这除与增大的前列腺阻塞尿道这一解剖因素有关,还与前列腺平滑肌张力有关。前列腺基质和色膜上有α肾上腺素能受体。用药刺激这些受体可使尿道平滑肌收缩和灌流压增高。用药阻滞这些受体的作用则相反。Alfuzosin是喹唑啉衍生物,可选择性地阻滞α_1受体。Jardin将其用于良性前列腺肥大以观察长期效益及安全性。共518例有症状的良性前列腺肥大患者被随机确
Benign prostatic hypertrophy is very common in the elderly. It can block the urethra and cause very nauseous urination symptoms. This is related to an anatomic factor that increases the prostatic obstruction of the urethra, but also to the tension of the prostate smooth muscle. Alpha-adrenoceptors on the prostate stroma and color film. Stimulation of these receptors can make urethral smooth muscle contraction and perfusion pressure increased. The effect of blocking these receptors is reversed. Alfuzosin is a quinazoline derivative that selectively blocks the alpha 1 receptor. Jardin uses it for benign prostatic hypertrophy to observe long-term benefits and safety. A total of 518 patients with symptomatic benign prostatic hypertrophy were randomized