宫内意外照射产后一年临床及染色体放射效应的研究

• 作 者: 王家锦 穆莹 王山来 王吉善 魏星 王代 魏艳秋 宋桂宁 王妍 徐玉娟 赵亚妹
• 机 构: 北京医科大学人民医院医学遗传科,北京医科大学人民医院医学遗传科,北京医科大学人民医院妇产科,北京医科大学人民医院医务处,北京医科大学人民医院医学遗传科,北京医科大学人民医院医学遗传科,北京医科大学人民
• 出 处: 优生优育
• 发表日期: 1995年01期
• 关键词: 头围 智力发育障碍 环形染色体 染色体损伤 外照射 染色体畸变 宫内胎儿 外周血染色体 临床效应 体格发育

本文报道一起宫内胎儿4个半月时受Co-60源意外照射,婴儿生后至1岁临床效应及外周血淋巴细胞染色体的放射损伤。婴儿生后身长、体重、头围均小于第3个百分位,1岁时除体格发育落后外,头围小于2个标准差,智力迟钝。母、婴产后及1岁时外周血染色体检查,其母亲染色体可见双着丝粒体、环形染色体等多种畸变,婴儿则未见到染色体畸变,姐妹染色单体交换率检查,受照婴儿生后姐妹染色单体交换率明显高于正常对照及产妇,1岁时检查则正常。

This article reports the intrauterine fetal 4 and a half months by Co-60 source accidental exposure to infants to 1 year old clinical effects and peripheral blood lymphocyte chromosome damage. After birth, the length, weight and head circumference of infants are less than the third percentile. At the age of 1, except for physical development, the head circumference is less than 2 standard deviations and mental retardation. Mother, after childbirth and 1 year old peripheral blood chromosomal examination, the mother of chromosomes can be seen crocidles, circular chromosomes and other distortions, infants did not see the chromosomal aberrations, sister chromatid exchange rate check, infants born to infants After the sister chromatid exchange rate was significantly higher than the normal control and maternal, 1-year-old examination was normal.