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目的研究服用二甲双胍治疗早期糖尿病的临床疗效。方法选取符合早期糖尿病标准的患者75例,采用随机、平行、开放、多中心的前瞻性观察,观察12周,测量三酰甘油(TG)、糖化血红蛋白Alc(HbAlc)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的变化。结果 12周治疗后,早期糖尿病患者TG、HbAlc、FPG、2hPG、LDL-C经治疗均有明显下降,HDL-C显著升高,治疗前后有显著性差异。结论二甲双胍作为早期糖尿病患者的首选药物,能使患者血糖水平下降,并有降血脂作用,是治疗早期糖尿病的有效药物。
Objective To study the clinical efficacy of metformin in the treatment of early stage diabetes. Methods A total of 75 patients with early-stage diabetes mellitus (T2DM) were enrolled. A randomized, parallel, open and multicenter prospective observational study was performed. The levels of triglyceride (TG), HbAlc, FPG, Changes of blood glucose (2 hPG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) at 2 h postprandial were observed. Results After 12 weeks of treatment, TG, HbAlc, FPG, 2hPG and LDL-C in early diabetic patients were significantly decreased after treatment, HDL-C was significantly increased, before and after treatment were significantly different. Conclusion As the drug of choice for patients with early stage diabetes mellitus, metformin can decrease the blood sugar level and have the effect of lowering blood fat. It is an effective drug for the treatment of early stage diabetes.