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目的:评价中药理冲汤加减方联合化疗治疗晚期卵巢癌的临床疗效。方法:将70例卵巢癌患者随机分为两组,治疗组(35例)于化疗第2天服用理冲汤加减方,水煎服每日1剂,至下1周期化疗开始,共20天;对照组(35例)单独使用化疗药物,化疗结束后不再用药。观察化疗药物消化道不良反应、患者生活质量、血液流变、血小板膜糖蛋白在治疗前后的变化,评价疗效。结果:两组治疗后与治疗前比较,血液流变高、中、低切值、血浆黏度、消化道反应、生活质量、CD62P表达,差异均有显著性(P<0.05);两组治疗后比较,血流变中、低切值、血浆黏度、消化道反应、生活质量、CD62P表达,差异均有显著性(P<0.05)。结论:理冲汤加减方联合化疗对晚期卵巢癌的治疗在减轻消化道反应方面疗效显著,可使患者血栓前状态得以改善,可能对减少卵巢癌病变复发转移有意义。
Objective: To evaluate the clinical curative effect of traditional Chinese medicine “Lipi Decoction” combined with chemotherapy in the treatment of advanced ovarian cancer. Methods: Seventy patients with ovarian cancer were randomly divided into two groups. The treatment group (35 cases) took Li Chong Decoction and Decoction on the second day of chemotherapy and the decoction of Shuijianbi for one day, and the next one cycle started chemotherapy for 20 days ; Control group (35 cases) chemotherapy alone, after chemotherapy no longer medication. To observe the adverse effects of chemotherapy drugs in the digestive tract, quality of life of patients, blood rheology, platelet glycoprotein changes before and after treatment to evaluate the efficacy. Results: After the treatment, the blood rheology was high, the medium and low cut values, the plasma viscosity, the digestive tract reaction, the quality of life, the expression of CD62P were significantly different between the two groups (P <0.05) In comparison, there was significant difference (P <0.05) between low blood flow value, low cut value, plasma viscosity, digestive tract reaction, quality of life and CD62P expression. CONCLUSION: The treatment of advanced ovarian cancer with the combination of Li-huantang decoction and chemotherapy is effective in reducing the gastrointestinal reaction, which can improve the prothrombotic state and possibly reduce the recurrence and metastasis of ovarian cancer.