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Objective:To exploretheexpressionof c-Mybgenein thebonemarrowcellof irradiatedmicetreated with rhBMP-2manditssignificance.Methods:By wayof RT-PCRandRNAdotblot,we observedtheexpressionof c-Myb geneinthebonemarrowcellsof micetreateddifferentlyon day10andday20afterirradiationrespectively.Results:On day10afterirradiation,theexpressionof c-Mybgeneinthebonemarrowcellof irradiatedmicetreatedwithrhBMP-2mis evidentlyhigherthanthatinnormalmice,andalsohigherthanthatonlytreated withirradiation.However,on day20after irradiation,thereareno evidentdifferencesin thethreegroups.Con clusion:c-Mybgenetakespartin therecoveryof hematopoiesisduringthestageof acuterecoveryinbonemarrow afterirradiation,andtheeffectis enhancedinthepartici-pationof rhBMP-2m.
Objective: To exploretheexpressionof c-Mybgenein thebonemarrowcellof irradiatedmicetreated with rhBMP-2manditssignificance.Methods: By wayof RT-PCRandRNAdotblot, we observedtheexpressionof c-Myb geneinthebonemarrowcellsof micetreateddifferentlyon day10andday20afterirradiationrespectively.Results: On day10afterirradiation, theexpressionof c-Mybgeneinthebonemarrowcellof irradiatedmicetreatedwithrhBMP-2mis evidentlyhigherthanthatinnormalmice, andalsohigherthanthatonlytreated withirradiation.However, on day 20 after irradiation, thereareno evident differences in the threegroups.Con clusion: c-Mybgenetakesparty therecoveryof hematopoiesisduringthestageof acuterecoveryinbonemarrow afterirradiation, andtheeffectis enhancedinthepartici-pationof rhBMP-2m.