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在抗Ｔｈｙ１．１抗体所致的大鼠系膜增殖性肾炎中，测定了白细胞衍生的血栓素（ＴＸ）及白三烯（ＬＴ）对肾小球血液动力学的作用。在肾炎鼠，肾小球超滤系数（Ｋｆ）、肾小球滤过率（ＧＦＲ）及肾血流量（ＲＢＦ）的急性降低伴有肾小球白细胞计数的升高及肾小球ＴＸＢ＿２、ＬＴＢ＿４的合成增多。白细胞除去可抑制ＴＸＢ＿２及ＬＴＢ＿４的合成并完全防止ＧＦＲ及ＲＢＦ的降低。合用ＴＸ合成酶抑制剂及花生四烯酸５－脂氧化酶抑制剂也防止了ＧＦＲ及ＲＢＦ的下降。分别应用ＴＸ合成酶或５－脂氧化酶抑制剂仅可部分防止ＧＦＲ及ＲＢＦ的降低。ＴＸ受体拮抗剂或５－脂氧化酶抑制剂可防止Ｋｆ的减少。这些资料说明浸润于肾小球的白细胞所衍生的ＴＸ、ＬＴ参与系膜增殖性肾炎模型的急性肾功能减退。
The effect of leukocyte-derived thromboxane (TX) and leukotriene (LT) on glomerular hemodynamics was measured in anti-Thy1.1 antibody-induced rat mesangial proliferative glomerulonephritis. In nephritis rats, the acute decrease of glomerular filtration rate (Kf), glomerular filtration rate (GFR) and renal blood flow (RBF) accompanied with the increase of glomerular leukocyte count and glomerular TXB_2, LTB_4 The synthesis of increased. Leukapheresis can inhibit the synthesis of TXB_2 and LTB_4 and completely prevent the decrease of GFR and RBF. Combined TX synthase inhibitors and arachidonic acid 5-lipoxygenase inhibitors also prevented a decrease in GFR and RBF. The use of TX synthase or 5-lipoxygenase inhibitors, respectively, only partially prevented a decrease in GFR and RBF. TX receptor antagonists or 5-lipoxygenase inhibitors prevent a decrease in Kf. These data demonstrate that TX, LT derived from leukocytes infiltrating glomeruli, is involved in acute renal dysfunction in a mesangial proliferative glomerulonephritis model.