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目的:通过对晚期胰腺癌患者行高强度聚焦超声治疗,观察其近期疗效,为晚期胰腺癌患者的临床治疗提供一种新的选择。方法:对15例晚期胰腺癌患者行高强度聚焦超声治疗,对比治疗前后的KPS评分,疼痛感受评分,CA199,三大常规,生化检查,B超观察肿瘤回声及血供,CT观察肿瘤大小改变。结果:HIFU治疗后,患者KPS评分升高,疼痛评分下降,肿瘤标志物下降,B超观察肿瘤回声,其中10例肿瘤回声增强,11例肿瘤血供减少或消失,CT示大部分患者治疗后肿瘤体积缩小或不变,治疗后三大常规、生化和电解质无明显改变。结论:运用高强度聚焦超声治疗晚期胰腺癌患者,在改善患者临床症状方面有明显疗效,并且能缩小肿瘤体积,减少或中断肿瘤血供,是一种很有发展前景的无创治疗方法。
OBJECTIVE: To observe the short-term effect of high-intensity focused ultrasound on patients with advanced pancreatic cancer and to provide a new option for the clinical treatment of patients with advanced pancreatic cancer. Methods: Fifteen patients with advanced pancreatic cancer underwent high-intensity focused ultrasound treatment before and after treatment. KPS score, pain score, CA199, three routine biochemical tests and B-ultrasound were used to observe tumor echogenicity and blood supply. . Results: After HIFU treatment, KPS scores increased, pain scores decreased, tumor markers decreased, B ultrasound observation of tumor echoes, including 10 cases of tumor echo enhancement, 11 cases of tumor blood supply decreased or disappeared, CT showed that most patients after treatment Tumor volume reduced or unchanged, after treatment of the three major conventional, biochemical and electrolyte no significant change. Conclusion: The use of high-intensity focused ultrasound in the treatment of patients with advanced pancreatic cancer has obvious curative effect in improving the clinical symptoms of patients and can reduce the tumor volume and reduce or interrupt the blood supply of the tumor. It is a promising noninvasive treatment method.