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循环免疫复合物在第Ⅲ型(即免疫复合物型)变态反应性疾病的发病机制中起着重要作用。因此,测定血清中循环免疫复合物的含量及其动态,对有关疾病的诊断、病程观察及发病机理的研究等,都具有一定的临床意义。目前检测循环免疫复合物的方法较多,而以Clq结合实验、Raji细胞二法为优。我们自1980年以来采用Volanakis等人的方法,从新鲜人血中快速提取Clq;再用Zubler等氏
Cyclic immune complexes play an important role in the pathogenesis of type III (ie, immunocomplex-type) allergic diseases. Therefore, the determination of serum levels of circulating immune complexes and their dynamics, the diagnosis of the disease, the duration of observation and pathogenesis of research, have some clinical significance. At present, there are many ways to detect circulating immune complexes, while Clq binding experiments are superior to Raji cells’ second method. We have been using Volanakis et al.’s method since 1980 to rapidly extract Clq from fresh human blood, and then use Zubler et al