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[目的]探讨南京市居民睡眠时间与2型糖尿病(T2DM)发生风险的关系。[方法]社区为基础的人群随访研究,2004年7月对多阶段随机抽取的南京市3个城区和1个郊县社区里常住的35岁以上居民进行基线调查,对无T2DM的人群开展为期3年的随访,于2007年7月进行评估调查。采用多因素Logistic回归方法分析睡眠时间与罹患T2DM风险之间的关联。[结果]剔除基线时T2DM、肿瘤患者,合格的随访样本人群为3727名,3年后共随访到3031名,随访率为81.3%。3年内新确诊的T2DM患者为76人,累计发病率为2.5%;男女发病率无统计学差异(2.5%vs.2.6%)。居民平均每天睡眠时间为7.2h,睡眠时间不足(﹤7h/d)和过长(≥9h/d)的比例分别为24.8%、7.5%。与睡眠时间7h/d相比,睡眠时间不足和过长人群罹患T2DM风险均是其2倍左右;但仅有睡眠不足对T2MD的罹患风险的影响差异有统计学意义(RR=1.83,95%CI:1.12～2.99)。经多因素调整后,睡眠时间﹤7h/d者发生T2DM的风险仍显著高于7～8h者(RR=1.71,95%CI:1.04～2.82);进一步调整基线时BMI和高血压病史,睡眠时间不足人群罹患T2DM风险有所降低,但差异仍有统计学意义(RR=1.68,95%CI:1.02～2.76)。[结论]睡眠时间不足可增加罹患T2DM的风险。睡眠时间可能是T2DM的危险因素之一。
[Objective] To investigate the relationship between the sleep time of Nanjing residents and the risk of type 2 diabetes mellitus (T2DM). [Methods] A community-based population follow-up study was conducted. In July 2004, a baseline survey was conducted among three urban areas in Nanjing and one resident in the suburbs in a suburban area randomly selected from multiple stages. The population without T2DM Three years of follow-up, in July 2007 assessment survey. Multivariate Logistic regression was used to analyze the association between sleep time and the risk of developing T2DM. [Results] The number of patients with T2DM, tumor patients and qualified follow-up samples excluding baseline was 3727. After 3 years, a total of 3031 patients were followed up with a follow-up rate of 81.3%. The number of newly diagnosed T2DM patients in 3 years was 76, with a cumulative incidence of 2.5%. There was no significant difference between men and women (2.5% vs 2.6%). The average daily sleep time for residents was 7.2h, and the percentage of sleep time deficient (<7h / d) and long (≥9h / d) were 24.8% and 7.5% respectively. Compared with sleep time 7h / d, people with sleep deprivation and overdose had twice the risk of T2DM. However, the effect of sleep deprivation on the risk of T2MD was statistically significant (RR = 1.83, 95% CI: 1.12 ~ 2.99). After adjusting for multivariate factors, the risk of T2DM with sleep duration less than 7h / d was still significantly higher than those with duration of 7-8h (RR = 1.71, 95% CI: 1.04-2.82); further adjusting for baseline BMI and history of hypertension, The risk of T2DM was reduced in under-aged population, but the difference remained statistically significant (RR = 1.68, 95% CI: 1.02-2.76). [Conclusion] Lack of sleep time can increase the risk of T2DM. Sleep time may be one of the risk factors for T2DM.