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作者报道1例克隆病人,女,20岁。消瘦、间断腹泻伴直肠出血6个月。直肠活检见克隆病特征性的肉芽肿病变,钡餐检查见弥漫性小肠克隆病。给予柳氮磺胺吡啶1 g,每天2次,强的松龙每天40mg,3周后出现严重的精神障碍。即住院治疗,停用强的松龙,改用氯丙嗪每天400mg,精神症状逐渐好转,但需用氯丙嗪维持4个月。随后1年内,病人仅服用柳氮磺胺吡啶,每天2～3 g,但症状不见缓解,体重下降、踝关节水肿伴低白蛋白血症,停经。开始给病人口服环孢菌素(cyclosporin)16mg/kg/d,连续1
The authors reported 1 patient cloned, female, 20 years old. Thin, intermittent diarrhea with rectal bleeding for 6 months. Rectal biopsy see Crohn’s disease characteristic granuloma, barium meal examination see diffuse enterocolitis. Sulfasalazine given 1 g, 2 times a day, prednisolone 40mg daily, 3 weeks after the emergence of serious mental disorders. That hospitalization, the withdrawal of prednisolone, switch to chlorpromazine 400mg per day, the psychiatric symptoms gradually improved, but need to use chlorpromazine for 4 months. In the next year, the patient took sulfasalazine only 2 to 3 g daily, but the symptoms did not relieve, weight loss, ankle edema with hypoalbuminemia and menopause. Patients were started oral cyclosporin (cyclosporin) 16mg / kg / d, continuous 1