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探讨硬化剂对小型香猪甲状腺组织病理和内分泌功能的影响。方法：５％的鱼肝油酸钠注射于小型香猪甲状腺内，使其硬化达９０％以上时，观察小香猪甲状腺在不同时间组织病理变化和内分泌功能变化。结果：①硬化剂剂量与硬化体积呈线性相关，Ｙ＝１．５Ｘ，②注射硬化剂后甲状腺有明显萎缩，滤泡塌陷，胶质浓缩，变性坏死，纤维结缔组织增生，③注射硬化剂后内分泌功能明显下降。结论：小型香猪甲状腺注射硬化剂后可相当于手术切除部分甲状腺组织，可能为临床治疗甲亢提供新方法
To investigate the effect of sclerosant on thyroid histopathology and endocrine function of miniature swine. Methods: When 5% sodium morrhuate was injected into the thyroid of the miniature pig, the histological changes and endocrine function of the thyroid gland were observed at different time. Results: ① The dose of sclerosant was linearly related to the volume of sclerosis, Y = 1.5X. ② Thyroid gland atrophy, follicular collapse, degeneration and necrosis, hyperplasia of fibrous connective tissue after injection of sclerosant. ③ After injection of sclerosant Endocrine function decreased significantly. Conclusion: Small thyroid injection of sclerosant thyroid can be equivalent to surgical removal of part of the thyroid tissue may provide a new method for the clinical treatment of hyperthyroidism