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目的研究滋养细胞肿瘤患者血清中的细胞因子水平，探讨与病因的关系。方法以双抗体、夹心ＥＬＩＳＡ法检测３０例滋养细胞肿瘤患者血清中肿瘤坏死因子及白细胞介素－６、８、１０的水平。其中绒毛膜癌１８例，侵蚀性葡萄胎１２例，并以正常早、中期妊娠妇女２８例、正常非孕妇２０例作为对照组。结果正常孕妇组ＩＬ－６、８、１０均高于正常非孕妇组，其中正常孕妇组ＩＬ－６和ＩＬ－８水平明显升高（Ｐ＜００１），而ＩＬ－１０水平略升高，无统计学意义。绒癌和侵蚀性葡萄胎患者血清中ＴＮＦ－α、ＩＬ－６、ＩＬ－８和ＩＬ－１０均明显高于正常非孕妇和正常妊娠妇女组（Ｐ＜００１）。结论滋养细胞肿瘤发生过程中存在着免疫功能的紊乱，细胞因子水平与滋养细胞肿瘤的发生相关。
Objective To study the serum levels of cytokines in patients with trophoblastic tumor and to explore the relationship with etiology. Methods Serum levels of tumor necrosis factor and interleukin-6, 8 and 10 in 30 patients with trophoblastic tumor were detected by double antibody and sandwich ELISA. There were 18 cases of choriocarcinoma and 12 cases of invasive hydatidiform mole. Twenty-eight normal pregnant women and 20 normal pregnant women were selected as the control group. Results The levels of IL-6, 8 and 10 in normal pregnant women were significantly higher than those in normal pregnant women, and the levels of IL-6 and IL-8 in normal pregnant women were significantly increased (P <001), while the levels of IL-10 were slightly increased , No statistical significance. Serum levels of TNF-α, IL-6, IL-8 and IL-10 in patients with choriocarcinoma and invasive hydatidiform mole were significantly higher than those in normal non-pregnant women and normal pregnant women (P <001). Conclusion Trophoblastic tumor has immune dysfunction during the tumorigenesis. The level of cytokines is related to the occurrence of trophoblastic tumor.