鼻恶性肿瘤病人血小板聚集功能的测定

• 作 者: 吉晓滨 农辉图 黄光武 谢成熹
• 机 构: 广州市第一人民医院耳鼻咽喉科!510180,广西医科大学第一附属医院耳鼻咽喉科,广西医科大学第一附属医院耳鼻咽喉科,广西医科大学第一附属医院耳鼻咽喉科
• 出 处: 临床耳鼻咽喉科杂志
• 发表日期: 1996年04期
• 关键词: 鼻恶性肿瘤 血小板聚集功能 远隔转移 血小板聚集试验 鼻肿瘤 血小板抑制剂 良性肿瘤组 外鼻 浆细胞肉瘤 混合瘤

对68例鼻恶性肿瘤病人进行血小板聚集试验,并以100例正常人和10例鼻良性肿瘤病人作对照.结果发现①恶性肿瘤中,治疗前组、复发组和远隔转移组血小板最大聚集率(MAR)均数高于正常组、良性肿瘤组和治疗后组(P<0.05);②治疗前组中MAR均数随肿瘤分期而增高.表明恶性肿瘤可引起血小板聚集增强.并就恶性肿瘤病人血小板聚集增强的机制.血小板在肿瘤生长、转移中的作用等进行讨论.还展望了血小板抑制剂在抗肿瘤的应用前景.

Sixty-eight patients with nasal malignancy were tested for platelet aggregation, and 100 healthy controls and 10 benign nasal benign tumors were used as control.Results: ①The maximum aggregation rate of platelets in pre-treatment group, recurrence group and distant metastasis group (P <0.05); ②The average number of MAR increased with the tumor stage before treatment, which indicated that the malignant tumors could cause the increase of platelet aggregation, and the average number of MAR was significantly higher than that of the normal group, benign tumor group and post-treatment group The mechanism of enhanced platelet aggregation in patients, the role of platelets in tumor growth and metastasis, etc. The prospect of anti-tumor application of platelet inhibitors is also prospected.