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Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing tryptophan degradation in the first, rate-limiting step towards biosynthesis of nicotinamide adenine dinucleotide (NAD). IDO has been commonly found elevated in tumor micro-environment and draining lymph nodes. IDO can be induced to express on dendritic cells which is responsible for immune tolerance to tumor antigens. It inhibits T cell response by the depletion of tryptophan and production of kyneurenine, which is toxic to lymphocytes. To ameliorate immune tolerance is an important prerequisite to achieve successful immunotherapy. To inhibit IDO activity using a competitive inhibitor, 1-methyl-tryptophan, is
Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing tryptophan degradation in the first, rate-limiting step toward biosynthesis of nicotinamide adenine dinucleotide (NAD). IDO has been commonly found elevated in tumor micro-environment and draining lymph nodes. IDO It inhibits T cell response by the depletion of tryptophan and production of kyneurenine, which is toxic to lymphocytes. To ameliorate immune tolerance is an important prerequisite to achieve successful immunotherapy. To inhibit IDO activity using a competitive inhibitor, 1-methyl-tryptophan, is