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长托宁(盐酸戊乙奎醚)是一种新型选择性的抗胆碱药[1],能与M、N胆碱受体结合,从而抑制节后胆碱能神经支配的平滑肌与腺体生理功能,对抗乙酰胆碱和其它拟胆碱药物的毒蕈碱样及烟碱样作用,它能透过血脑屏障,故同时具有较强且全面的中枢和外周抗胆碱作用。对M受体具有明显选择性,即主要选择作用于M1、M3受体,而对M2受体的作用较弱或不明显[2],不阻断突触前膜M2受体调控神经末梢释放Ach的功能,稳定心率。同时,对
Penehyclidine hydrochloride (penehyclidine hydrochloride) is a new and selective anticholinergic drug [1] that binds to M and N cholinergic receptors and thus inhibits the physiological function of the smooth muscle and gland in the post-sympathetic cholinergic innervation, Against the muscarinic and nicotinic effects of acetylcholine and other cholinergic drugs that cross the blood-brain barrier, they have both strong and comprehensive central and peripheral anticholinergic effects. M receptor obvious selectivity, that is, the main choice of role in the M1, M3 receptor, while the role of M2 receptor is weak or insignificant [2], does not block the presynaptic membrane M2 receptor regulation of nerve endings release Ach’s function to stabilize heart rate. At the same time, right