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目的探讨TSP-1和VEGF在乳腺癌的浸润、转移、复发和预后中的作用。方法对180例乳腺癌患者进行随访,结合TSP-1、VEGF表达情况,研究乳腺癌患者的复发、转移与TSP-1、VEGF的表达水平之间的关系。结果 TSP-1(+)病例的复发率较TSP-1(-)病例的复发率低。VEGF(+)病例的复发率较VEGF(-)病例的复发率高。结论 TSP-1是重要的血管生成抑制因子,在一定程度上限制了乳腺癌的复发和转移。VEGF是重要的血管生成促进因子,在乳腺癌的复发和转移中起重要的促进作用。
Objective To investigate the role of TSP-1 and VEGF in infiltration, metastasis, recurrence and prognosis of breast cancer. Methods 180 cases of breast cancer patients were followed up. The expression of TSP-1 and VEGF in breast cancer patients were studied with TSP-1 and VEGF expression. Results The recurrence rate of TSP-1 (+) cases was lower than that of TSP-1 (-) cases. The recurrence rate of VEGF (+) cases was higher than that of VEGF (-) cases. Conclusion TSP-1 is an important angiogenesis inhibitor, to a certain extent, limited the recurrence and metastasis of breast cancer. VEGF is an important angiogenesis promoting factor that plays an important promoting role in the recurrence and metastasis of breast cancer.