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目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清S-100β和神经元特异性烯醇化酶(NSE)水平变化及其与认知功能的相关性。方法选取2015年8月—2016年10月重庆医科大学附属永川医院耳鼻咽喉头颈外科收治的OSAHS患者88例,根据夜间最低氧饱和度(LSa O2)和呼吸暂停低通气指数(AHI)分为轻度OSAHS组24例、中度OSAHS组30例和重度OSAHS组34例;另选择同期体检健康男性志愿者26例作为对照组。比较4组受试者血清S-100β、NSE水平及蒙特利尔认知评估量表(Mo CA)评分,血清S-100β、NSE水平与OSAHS患者Mo CA评分的相关性采用Pearson相关分析。结果轻度OSAHS组、中度OSAHS组、重度OSAHS组患者血清S-100β水平高于对照组(P<0.05);4组受试者血清NSE水平比较,差异无统计学意义(P>0.05)。轻度OSAHS组、中度OSAHS组、重度OSAHS组患者Mo CA评分低于对照组,重度OSAHS组患者Mo CA评分低于轻度OSAHS组、中度OSAHS组(P<0.05)。血清S-100β水平与OSAHS患者Mo CA评分呈负相关(r=-0.398,P<0.05),而血清NSE水平与OSAHS患者Mo CA评分间无直线相关性(r=0.029,P>0.05)。结论 OSAHS患者血清S-100β升高、认知功能下降,血清S-100β水平升高及其造成的脑损伤可能与OSAHS患者认知功能下降相关。
Objective To analyze the changes of serum S-100β and neuron-specific enolase (NSE) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its relationship with cognitive function. Methods Eighty-eight OSAHS patients admitted to Yongchuan Hospital Affiliated to Chongqing Medical University from August 2015 to October 2016 were divided into two groups according to nighttime LSaO2 and AHI 24 cases of degree OSAHS group, 30 cases of moderate OSAHS group and 34 cases of severe OSAHS group. Another 26 healthy volunteers were selected as the control group. Pearson correlation analysis was used to analyze the correlation between serum S-100β, NSE level and Montreal MoCA score, S-100β, NSE level and MoCA score in patients with OSAHS. Results Serum levels of S-100βin mild OSAHS group, moderate OSAHS group and severe OSAHS group were significantly higher than those in control group (P <0.05). There was no significant difference in serum NSE levels between the four groups (P0.05) . MoCA scores in patients with mild OSAHS, moderate OSAHS and severe OSAHS were lower than those in control group. MoCA scores in patients with severe OSAHS were lower than those in mild OSAHS group and moderate OSAHS group (P <0.05). The level of serum S-100βwas negatively correlated with MoCA score in patients with OSAHS (r = -0.398, P <0.05). There was no linear correlation between serum NSE level and MoCA score in patients with OSAHS (r = 0.029, P> 0.05). Conclusions Serum S-100β level is elevated in OSAHS patients with decreased cognitive function. Elevated serum S-100β levels and brain damage may be associated with decreased cognitive function in patients with OSAHS.