强烈化疗治疗Ph~1(+)急性淋巴细胞白血病

• 作 者: 何学鹏
• 出 处: 国外医学.输血及血液学分册
• 发表日期: 1994年05期
• 关键词: Ph~1 诱导治疗 左旋门冬酰胺酶 鬼臼噻吩甙 免疫分型 柔红霉素 大剂量氨甲喋呤 白血病细胞 巩固治疗 CNSL

单用化疗对典型Ph~1(+)的儿童急性淋巴细胞白血病(ALL)的疗效甚差,本文报告采用强烈化疗治疗11例Ph~1(+)ALL患儿的结果。 患者年龄2～17岁,2例有中枢神经白血病(CNSL),免疫分型6例为早期前B型,5例为前B型,核型分析均有t(9;22)(q34;q11)。诱导治疗包括强的松、长春新碱、左旋门冬酰胺酶、柔红霉素、鬼臼噻吩甙和阿糖胞苷;巩固治疗为大剂量氨甲喋呤

The effect of chemotherapy alone is very poor in children with typical Ph ~ 1 (+) childhood acute lymphoblastic leukemia (ALL). We report the results of intensive chemotherapy in 11 children with Ph-1 (+) ALL. The patients were 2 to 17 years old, 2 had central nervous cell leukemia (CNSL), 6 had early pre-B type, 5 had pre-B type, and karyotype analysis had t (9,22) (q34; q11 ). Induction therapy included prednisone, vincristine, levamisole, daunorubicin, teniposide and cytarabine; consolidation therapy for high-dose methotrexate