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Background:Osteoarthritis belongs to regressive diseases.A lot of inflammatory cells were observed in inflammatory tissues.Shipeite was the sodium hyaluronate extracted from cockscomn which is the main elements of artucykar cartilage and synovial fluid.Objective:To reduce pain caused by gonarthritis through shipeite injection of articular cavity and acupoint. Design:According to diagnosis criteria for osteoarthritis of American Rheumatology Association,181 patients with gonarthritis were included in our study. Unit:Peoples Hospital of Jiangxi.