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目的探讨苦参碱注射液防治胸部肿瘤放疗所致的放射性肺损伤的疗效。方法将病理检查证实且需进行放疗的胸部肿瘤患者85例随机分为2组。治疗组43例于放疗第1天起静脉滴注苦参碱注射液;对照组42例给予单纯放疗。比较2组血清肿瘤坏死因子(TNF-α)水平、KPS评分以及随访6个月期间放射性肺损伤的发生率。结果 2组患者放疗2周及放疗结束时TNF-α水平显著升高,而治疗组升高幅度显著低于对照组。治疗组放疗2周及放疗结束时KPS评分较放疗前略有下降,而放疗结束后6个月显著升高,且放疗结束时及结束后6个月均显著高于对照组;治疗组早期及晚期放射性肺损伤的发生率均显著低于对照组。结论苦参碱注射液具有减少炎症因子释放和提高KPS评分作用,可有效预防放射性肺损伤,提高患者生活质量。
Objective To investigate the efficacy of matrine injection in preventing and treating radiation-induced lung injury caused by radiotherapy of thoracic tumors. Methods Totally 85 patients with chest tumor confirmed by pathology and needing radiotherapy were randomly divided into 2 groups. In the treatment group, 43 cases received matrine injection intravenously on the first day of radiotherapy and 42 cases in the control group received radiotherapy alone. The levels of serum tumor necrosis factor (TNF-α), KPS score and the incidence of radiation-induced lung injury at 6-month follow-up were compared between the two groups. Results The levels of TNF-α in two groups were significantly increased at 2 weeks and the end of radiotherapy, while those in the treatment group were significantly lower than those in the control group. The KPS score of the treatment group decreased slightly 2 weeks after radiotherapy and the end of radiotherapy, but increased significantly 6 months after the end of radiotherapy. At the end of radiotherapy and 6 months after the end of radiotherapy, the KPS score was significantly higher than that of the control group. The treatment group early and late The incidence of radiation-induced lung injury were significantly lower than the control group. Conclusion Matrine injection can reduce the release of inflammatory cytokines and improve the KPS score, which can effectively prevent radiation-induced lung injury and improve the quality of life of patients.