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目的观察慢性丙型肝炎患者予聚乙二醇干扰素联合利巴韦林抗病毒治疗前后中医证型的变化。方法采用前瞻性研究方法,对54例慢性丙型肝炎患者应用聚乙二醇干扰素联合利巴韦林治疗,收集患者治疗前后的中医证候资料,并进行统计学分析。结果 54例患者治疗前后中医症状乏力、脘闷腹胀、烦燥易怒、情绪郁闷、寐差、面色萎黄、面色晦暗及舌边尖齿痕与舌质瘀点瘀斑发生率较前增多,差异有统计学意义(P<0.05)。治疗前中医证型分布规律为正虚邪恋证>肝郁脾虚证>肝肾阴虚证>湿热中阻证>脾肾阳虚证>瘀血阻络证;治疗后中医证型分布规律为肝郁脾虚证>正虚邪恋证>瘀血阻络证>脾肾阳虚证>湿热中阻证=肝肾阴虚证;治疗后肝郁脾虚证及瘀血阻络证患者比治疗前明显增多,差异有统计学意义(P<0.05)。结论聚乙二醇干扰素联合利巴韦林抗病毒治疗可对中医证型分布规律产生影响,主要表现为肝郁脾虚证及瘀血阻络证的增多。
Objective To observe the changes of TCM syndromes in patients with chronic hepatitis C before and after treatment with peginterferon and ribavirin antiviral therapy. Methods Fifty-four patients with chronic hepatitis C were treated with peginterferon combined with ribavirin. The data of TCM syndromes before and after treatment were collected and statistically analyzed. Results Before and after treatment, 54 patients had symptoms of fatigue, bloating, irritability, irritability, depressed mood, poor sleepiness, pale complexion, dull eyes, sharp tongue marks and ecchymosis of tongue. The difference was statistically significant There was statistical significance (P <0.05). Before treatment, TCM syndromes were distributed as positive love affair card> liver depression and spleen deficiency syndrome> liver and kidney yin deficiency syndrome> damp-heat resistance syndrome> spleen and kidney yang deficiency syndrome> blood stasis syndrome; after treatment, the distribution pattern of TCM syndromes was Liver Depression and Spleen Deficiency> Zhengxie evil love card> blood stasis network card> spleen and kidney yang card> damp heat block card = liver and kidney yin deficiency; after treatment of liver stagnation spleen deficiency syndrome and blood stasis network card before treatment Significantly increased, the difference was statistically significant (P <0.05). Conclusion Pegylated interferon combined with ribavirin antiviral therapy may have an impact on the distribution of TCM syndromes, mainly manifested as an increase of stagnation of liver-qi and spleen-deficiency syndrome and blood-stasis blocking syndrome.