论文部分内容阅读
新型隐球菌是一种环境腐生菌,但有时可存在于人的口咽部而可能成为肺和消化道内源性感染的病原。此菌如何吸附于粘膜表面,定居的诱因及如何从共生菌转成致病菌尚不清楚。有人曾在免疫功能正常的普通动物胃内接种大量新型隐球菌,证实本菌不易定居于该动物的消化道。为了解缺乏T细胞是否影响该菌在粘膜的定居与播散,作者用无菌BALB/c裸鼠(nu/nu)及杂合(nu/+)小鼠经口接种有荚膜的新型隐球菌(血清型
Cryptococcus neoformans is an environmental saprophytic bacterium that can sometimes be found in the oropharynx of humans and may be the causative agent of endogenous infections in the lungs and digestive tract. How the bacteria adsorb to the mucosal surface, the causes of colonization, and how to change from symbiotic bacteria to pathogens is unclear. Some people have normal immunocompetent stomach of ordinary animals vaccinated a large number of Cryptococcus neoformans confirmed that the bacteria are not easy to settle in the animal’s digestive tract. To understand whether the lack of T cells affect the colonization and spread of the bacteria in the mucosa, the authors used a novel inoculation of a capsule with sterile BALB / c nu / nu mice and heterozygous (nu / +) mice Cocci (serotypes